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REFORM MD ℞Telehealth • Wellness • Longevity
Treatment Comparison

Semaglutide vs Tirzepatide

& Microdose vs Standard GLP-1

Understand the key differences between your provider-guided GLP-1 options. Your prescribing provider makes the final decision based on your clinical evaluation.

RECEPTOR PATHWAYS

Semaglutide vs Tirzepatide

Both are provider-guided compounded GLP-1 options. The key difference is how many metabolic pathways they act on.

Reform MD Rx Semaglutide vial
GLP-1 receptor agonist

Semaglutide

Mimics the body's natural GLP-1 hormone to support appetite regulation and metabolic health.

From $218.99Explore
Reform MD Rx Tirzepatide vial
Dual GIP & GLP-1 receptor agonist

Tirzepatide

Acts on two metabolic pathways (GIP and GLP-1) to support appetite regulation and glucose metabolism.

From $262.99Explore
Feature
Semaglutide
Tirzepatide
Receptor pathway
GLP-1 only
GIP + GLP-1 (dual)
Mechanism
Mimics natural GLP-1 hormone
Activates two metabolic pathways
Supply options
4-Week & 12-Week
4-Week & 12-Week
Starting price (4-week)
$218.99
$262.99
Pharmacy
Nova Specialty Pharmacy
Nova Specialty Pharmacy
Excluded states
AL, CA, MS
AL, CA, MS
Prescription guaranteed?
No — provider decides
No — provider decides
DOSE APPROACH

Microdose vs Standard GLP-1

Microdosing is an individualized lower-dose approach — not a different medication. It uses the same active ingredient at a provider-selected lower dose based on your health history and tolerability.

Standard Dose

Follows an established titration schedule with 4-week and 12-week supply options. The provider selects the appropriate dose from the listed options based on your clinical evaluation.

Standard SemaglutideStandard Tirzepatide

Microdose

An individualized lower-dose approach selected with a provider based on your health history, treatment response, and tolerability. Available as a 4-week supply only. Evidence for microdosing is limited, and lower doses can still cause side effects.

Explore Microdosing
Feature
Standard
Microdose
Dose approach
Standard titration schedule
Individualized lower dose
Receptor pathway
Same as standard (GLP-1 or dual)
Same pathway, lower dose
Supply
4-Week & 12-Week
4-Week only
Who decides the dose
Prescribing provider
Prescribing provider
Evidence base
Established titration protocols
Limited evidence; side effects still possible
Weight loss guaranteed?
No — results vary
No — results vary
FREQUENTLY ASKED QUESTIONS

GLP-1 comparison questions

Semaglutide is a GLP-1 receptor agonist, acting on a single metabolic pathway. Tirzepatide is a dual GIP and GLP-1 receptor agonist that acts on two metabolic pathways. Your provider determines which is appropriate based on your clinical evaluation, health history, and treatment goals.

Important to know

  • Compounded medications are not FDA-approved.
  • No specific outcome, including weight loss, is guaranteed.
  • Your provider chooses the medication and dose based on your evaluation.
  • Both options include discreet 3 to 5 day home delivery.

Not sure which is right for you?

That's exactly what your provider helps determine during your evaluation.

Start Your Evaluation